A mosaic of domains jean gruenberg organelles in the endocytic pathway are composed of a mosaic of structural and functional regions. The vacuolar import and degradation pathway merges with. Although the vid vesicle pathway appears to merge with the endocytic pathway, our data indicate that this merger may be controlled by the vam3 gene. Endocytic and secretory traffic in arabidopsis merge in the transgolgi networkearly endosome, an independent and highly dynamic organelle. Anderson department of cell biology and neuroscience, university of texas southwestern medical center, dallas, texas, u. Multiple endocytic pathways connecting repositories. In the endocytic pathway, rab5 has been implicated in endocytosis and. In particular, whether detergentresistant membrane proteins, such as gpianchored proteins, would traffic in this pathway and whether we could define the requirements for endocytosis without clathrin. Cellular uptake of cyclotide mcotii follows multiple endocytic pathways. Cd1d molecule follows the secretory pathway from the er to the. Bidirectional traffic between the golgi and the endosomes. These regions consist, at least in part, of specialized proteinlipid domains within the plane of the membrane, or of protein complexes associated with specific membrane lipids. Recently, several clathrinindependent endocytic pathways have been identified, which represent the main pathway of entry into cells for a diverse. How does endocytosis modulate receptor signaling and vice versa.
The late chlamydial inclusion membrane is not derived from. We propose that sec28p resides on vid vesicles, and these vesicles later merge with the endocytic pathway. From there they again diverge along distinct sorting pathways, back to the cell surface, on to the transgolgi network or across polarized cells. The late chlamydial inclusion membrane is not derived from the endocytic pathway and is relatively deficient in host proteins. In this model, the lipid rafts can be merged into largescale stabilized structures9. Endocytic pathways and intracellular transport of aptamer.
Endocytosis of wingless via a dynaminindependent pathway is. In plant cells, fm464 becomes localized to the golgi, pvc and vacuolar membrane after 30min of staining, and to many organelles involved in the secretory and recycling pathways, as well as the endocytic pathway, by 60min ref. Pdf endocytic and secretory traffic in arabidopsis merge. The yeast rab5 homologue, vps21p, is known to be involved both in the vacuolar protein sorting vps pathway from the transgolgi network to the vacuole, and in the endocytic pathway. Bifurcation of the endocytic pathway into rab5dependent. Endophilina2mediated endocytic pathway is critical for enterovirus 71 entry into caco2 cells shenglin chena,b, yangang liua, yongtao zhoua,c, ping zhaoa, hao rena, man xiaob, yongzhe zhua and zhongtian qia adepartment of microbiology, shanghai key laboratory of medical biodefense, second military medical university shanghai, peoples. Merged images of gfp and mcherry channels are shown in the lower panel. Endocytic pathways and intracellular transport of aptamerdrug conjugates in live cells monitored by singleparticle tracking cheng lv institute of molecular medicine imm, state key laboratory of oncogenes and related genes renji hospital, shanghai jiao tong university school of medicine, and college of chemistry and chemical engineering.
Regulation of membrane transport through the endocytic pathway by. Pathways of clathrinindependent endocytosis nature. Endophilina2mediated endocytic pathway is critical for. E ndocytosis probably evolved in eukaryotic cells because of the selective advantage it conferred on cells that could utilize diverse, extracellular sources of nutrients.
Intriguing connections between signaling molecules and endosomes were revealed, and the increasing efforts to merge model systems. Interactions between the exocytic and endocytic pathways in. Characterization of a nonclathrin endocytic pathway. Endocytic and secretory traffic in arabidopsis merge in the transgolgi networkearly endosome, an independent and highly dynamic organelle article pdf available in the plant cell 224. Trafficking through the endocytic pathway presentation to nkt cells. The vacuolar import and degradation pathway merges with the. Bifurcation of the endocytic pathway into rab5dependent and.